Cannabis To Treat Autism has all kinds of new scientific breakthroughs that we want to inform you about in this article. A neurological abnormality called autism spectrum disorder affects how a person perceives and interacts with others, leading to social interaction and communication issues. ASD can be diagnosed in people of various sexes, racial and ethnic backgrounds, and socioeconomic statuses, even though ASD can be a lifelong illness. Early-infancy symptoms of autism spectrum disorder include limited eye contact, a lack of responsiveness to their name, or a lack of interest in caretakers. The affected children are intelligent, with normal to high IQs, but struggle with social interaction, communication, and application of knowledge. The cause of autism spectrum disorder is unknown, but there are probably numerous causes of ASD. For instance, ASD appears to be genetically influenced by several distinct genes. Autism spectrum disorder may be linked to a genetic condition in some kids. Researchers are actively looking into whether substances, including air pollution, pregnancy difficulties, drugs, or virus infections, can cause autism spectrum disorder. Early diagnosis and intervention are the best course of action to enhance a child’s behavior, abilities, and language growth.
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Now, let’s get into the use of cannabis to treat autism!
Overview of Cannabis
Cannabis sativa, Cannabis indica, and Cannabis ruderalis all refer to a group of three psychotropic plants. Some refer to it as weed, pot, and marijuana. Names for marijuana are changing as more jurisdictions legalize it. Cannabis plays a significant role in the medical field and is typically used for its soothing and sedating properties.
Origin
The hemp or cannabis plant first appeared in Central Asia, then was transported by people to Africa, Europe, and ultimately the Americas.
History
Cannabis was first used in western China or central Asia. People have used cannabis for its purported medicinal benefits for thousands of years. Its use was first recorded in 2800 BC when it was included in the pharmacopeia of Emperor Shen Nung, regarded as the founder of Chinese medicine.
The function of cannabis components in autism spectrum disorder
People with autism and their families have been experimenting with medicinal marijuana and items made from it more frequently during the past ten years. Only one cannabis-derived medication has received FDA approval to date, Epidiolex. It is a liquid cannabis extract with pure CBD that can lessen seizures in persons with tuberous sclerosis complex and Dravet syndrome or Lennox-Gastaut syndrome, severe forms of epilepsy occasionally associated with autism. Only these conditions are eligible for its availability, and only with a prescription. The manufacturer of Epidiolex, GW Pharmaceuticals, is testing the medication for Rett syndrome, a neurological disorder associated with autism. The Rett syndrome trial aims to improve cognitive and behavioral issues rather than reduce seizures. In addition, the business is seeking autistic kids and teenagers for a phase 2 trial of cannabidivarin, another cannabis compound.
Mechanism of action of cannabis against ASD
There is still much to learn about the precise processes by which CBMPs affect patients with autism. Dysregulated ECS has been hypothesized as unifying the pathophysiology of autism regardless of specific aetiologies based on data from various animal models of autism, human studies, and clinical experience. In both genetic and environmental animal models of autism, activation of the ECS has been demonstrated to lessen the symptoms and behaviors associated with the condition while enhancing cognitive ability. In several monogenetic models like Fmr1, neuroligin, and BTBR, controlling ECS improves the social and cognitive impairments in the affected animals. Similar to this, valproic acid immune activation and early inflammatory models of autism that are caused by the environment also reverse neurochemical abnormalities and aberrant neurodevelopment when given cannabidiol.
Cannabis’s history as an autism treatment
A 2006 study on 10 individuals was one of the first to look at the possible effects of medical cannabis for treating autism. Dronabinol (delta-9-THC), a cannabis-based drug, was given to adolescent patients with autism, intellectual difficulties, and self-harming tendencies (SIB). Seven out of ten patients had a significant and long-lasting improvement in the SIB as well as their general wellness and mood (Kruger and Christophersen 2006). Another case report from 2010 described how dronabinol treatment significantly and permanently reduced an autistic child’s hyperactivity, lethargy, irritability, stereotypy, and inappropriate speech (Kurz and Blaas 2010). A succinct report on the use of cannabis extracts high in cannabidiol to treat 60 autistic children between the ages of 5 and 18 was released in 2018 by the Journal of Autism and Developmental Disorders. The dosage was increased to achieve the desired effects and tolerability over a period of two to four weeks using a formulation with a 20:1 CBD: THC ratio. Improvements in behavior (61%), anxiety (39%), and communication (47%) were seen after receiving treatment (Aran et al. 2019).
Cannabis treatment options for autism spectrum disorder
There are a total of more than 120 cannabinoids, or cannabis constituents. Tetrahydrocannabinol (THC) and cannabidiol are the two most widely used and researched cannabinoids (CBD). Here, we will talk about CBD’s potential medical benefits.
Cannabis Inhalation
Other methods of making cannabis accessible exist, however about two-thirds of patients prefer inhaling smoke or vapor.
Edible Forms Of Cannabis Such As Gummies
The most common cannabinoid in edible cannabis products is cannabidiol (CBD), with some edibles also containing trace quantities of THC. Cannabis edibles’ key trait is that they take longer to take effect than cannabis smoked does.
Using Cannabis Oil
Hash oil, commonly known as honey oil or cannabis oil, is an oleoresin derived from cannabis or hashish. This cannabis concentrate contains numerous of the plant’s resins and terpenes, as well as tetrahydrocannabinol (THC), cannabidiol (CBD), and other cannabinoids.
Capsules
Like other pills, CBD capsules are taken by swallowing them. While dosing is simple, experiencing any effects may take some time.
Topicals
Applying CBD creams, lotions, balms, and patches directly to the skin provides immediate relief.
Scientific evidence that cannabis is used to treat ASD
Only one cannabis-derived medication has received FDA approval to date, Epidiolex. It is a liquid cannabis extract with pure CBD that has been shown to reduce seizures in persons with Lennox-Gastaut syndrome and Dravet syndrome, two severe forms of epilepsy that can occasionally be combined with autism. Due to the success of Epidiolex, many parents have tried marijuana and cannabis extracts to treat their children’s seizures, behavioral problems, and other autism-related traits. However, experts caution that these drugs have not been extensively studied for these uses. CBD might not be enough to give cannabis its medicinal benefits. A 2018 study reveals that a CBD to THC ratio of 1 to 20 reduces aggressive outbursts in autistic children. Numerous research has demonstrated that the minor adverse effects of cannabis therapy, such as drowsiness or restlessness, are minimal. However, these studies did not examine long-term negative effects.
Top cannabis strains for treating ASD
Green Crack
A Sativa-dominant hybrid strain containing Skunk #1 DNA is called Green Crack. It has been used to treat autistic tension and hostility since it is the ultimate wake-and-bake strain. It has also been used to improve focus and concentration in autistic individuals.
Blue Dream
This hybrid strain, which is Sativa-dominant, is from California. Blue Dream cannabis strain is effective at numbing pain and discomfort associated with autism. If you like to learn more about Blue Dream check out our post – Blue Dream Strain
LA Confidential
This potent Indica strain causes complete body relaxation. It has been applied to persons with autism spectrum disorders to induce relaxation and lessen social anxiety. If you like to learn more about LA Confidential strain check out our post – LA Confidential Strain
Sour Diesel
Sour Diesel is a high-THC, Sativa-dominant strain known for its cerebral and energizing effects. Since people with autism may have issues socializing, Sour Diesel may provide blissful and invigorating effects to improve socialization. If you like to learn more about Sour Diesel strain check out our post – Lemon Sour Diesel Strain
Charlotte’s Web
A common marijuana strain that is high in CBD and low in THC. It has long been the preferred strain for treating pediatric epilepsy, and now it is gaining popularity as a possible preferred strain for autism.
If you would like to find out more about all the major popular strains, check out our post – Weed Strains
Why choose cannabis
People who suffer from autism spectrum disorder may consider taking cannabis for a variety of reasons. In addition to the traditional therapies already in use, alternative therapies are preferred. Cannabis is regarded as natural and secure. The usage of cannabis is becoming more common and less taboo. There might be a benefit as an alternative to opioids and other medications. Legalizing marijuana might make it possible to conduct more clinical research on how it impacts the management of ASD. According to a recent study by Daniel Kruger of the University of Michigan Institute for Social Research, 44% of medicinal marijuana users substituted cannabis for one or both prescription medications.
Chemical terpenes of cannabis used for ASD
The largest and most diversified collection of naturally occurring substances is comprised of terpenes, sometimes referred to as terpenoids. naturally occurring chemical compounds found in plants and some animals. About 400 terpenes have been identified in cannabis. Ginseng contains a terpene called humulene that has stimulating properties and has been utilized in traditional medicine for a long time. Mangoes contain the chemical myrcene, which has sedative effects and antifungal and antibacterial characteristics. Remember that a lot of the terpenes research is still in its infancy. To completely comprehend the effects that various terpene profiles have on health, more high-quality research in people is required.
Challenges to managing autism disorder via cannabis
Medical marijuana is being considered a potential therapy option by more and more parents of kids with severe autism spectrum disorder. But the matter poses complex legal and moral issues. Even some specialists are still torn. Media stories and anecdotes about the use of medical marijuana to treat severe ASD are common. Despite anecdotal evidence suggesting that marijuana can treat the most severe ASD symptoms, scientific research has not conclusively supported this claim. Furthermore, it has not been proven that providing children with medical cannabis is secure. However, a lot of parents of severely autistic children are keen to explore every alternative. A diagnosis of autism is distressing. Families with children, particularly those with severe forms of ASD, are greatly impacted, and the parents of these children are desperately searching for solutions.
Cannabis and its ability to reduce the risk of autism
It is still not completely established what causes autism spectrum disorder (ASD). Researchers have found evidence of an imbalance in the endocannabinoid (eCB) system, which controls some bodily processes that are frequently hampered in ASD, such as emotional reactions and social interaction, among other biological ideas. Additionally, the non-intoxicating component of Cannabis sativa known as cannabidiol (CBD) has just received approval for the treatment of treatment-resistant epilepsy. A prevalent medical problem among those with ASD is epilepsy. Additionally, there are certain neuropathological mechanisms between the two diseases, specifically dysfunctions of the GABAergic system. Cannabinoids were therefore thought to be helpful in easing ASD symptoms. It is interesting to note that in patients with concomitant epilepsy, cannabis is typically permitted to reduce the number of prescribed medications and decreased the frequency of seizures. The excitatory/inhibitory imbalance seen in ASD patients may be related to mechanisms of action. However, more tests that better characterize and homogenize materials and have outcomes that are well specified should be conducted. Researchers began to speculate that phytocannabinoids, which are found naturally in the Cannabis sativa plant, would have a positive impact on the primary and comorbid symptoms of ASD in light of the changes in the eCB systems.
Conclusion Use Of Cannabis To Treat Autism
Autism spectrum disorder is a neurological condition that impairs a person’s perception of and interactions with other people. People of different sexes, racial and ethnic backgrounds, and socioeconomic positions can be diagnosed with ASD. We got to the conclusion that patients with ASD and its related symptoms are improved by cannabis use. Numerous studies have shown that cannabis helps treat Autism spectrum disease and lessen its symptoms. More research and clinical trials are necessary to properly comprehend whether cannabis may effectively treat ASD and its symptoms.
Thank you for reading about Cannabis To Treat Autism. We have many more articles that explain how cannabis can help with many illnesses written by medical doctors. Check those out in our blog section.
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