Cannabis for bone fractures and strengthing has all kinds of new scientific breakthroughs. A shattered bone is referred to medically as a bone fracture. Traumas like falls, auto accidents, or sports injuries frequently result in fractures. However, certain medical problems and repetitive motions (like running) can raise your chance of developing a certain kind of fracture. Because osteoporosis weakens bones, they are more prone to sudden, unforeseen fractures. Osteoporosis is caused by a lifelong deficiency in calcium. In the case of an open fracture, additional symptoms may include bleeding as well as pain, swelling, bruising, discolored skin around the injured area, protrusion of the injured area at an unusual angle, inability to bear weight on the injured area, immobility of the injured area, and a grating sensation in the affected bone or joint. Cannabis, a psychoactive substance derived from the Cannabis plant, is sometimes referred to as marijuana and other names. The cannabis plant, which is indigenous to Central and South Asia, has been used for ages in traditional remedies and as a medication for both pleasure and entheogenic uses.
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Now, let’s get into the use of cannabis for bone fractures and strengthing!
History Of Cannabis Use
Cannabis has a lengthy and interesting past. Cannabis was first used in western China or central Asia. For thousands of years, people have utilized cannabis for its purported medicinal benefits. Its use was first recorded in 2800 BC when it was included in the pharmacopeia of Emperor Shen Nung, who is regarded as the founder of Chinese medicine. The scriptures of the Indian Hindus, the Assyrians, the Greeks, and the Romans all describe the therapeutic uses of cannabis. This
literature claimed that cannabis could be used to treat a wide range of ailments, including asthma, amenorrhea, inflammation, pain, arthritis, depression, and loss of appetite. Cannabis extracts were available to treat stomach issues and other disorders by the late 1800s in pharmacies and medical offices across Europe and the US. Later, researchers found that THC was the substance responsible for marijuana’s therapeutic effects. THC, the psychoactive component in marijuana that causes its mind-altering effects, also interacts with parts of the brain that can alleviate nausea and increase appetite. In reality, Marinol and Syndros, two THC-containing medications that are taken in pill form, have received approval from the U.S. Food and Drug Administration to treat nausea brought on by cancer treatment and appetite loss in AIDS patients. Now researchers are aiming to find out the benefits and cannabis contribution to bone fracture.
Human Body; Cannabis System
The skeleton, along with other vital and non-vital systems, is regulated by the cannabinoid system that the human body is inherently endowed with, claims Gabet. We have innate molecules and receptors that can also be activated by substances in the cannabis plant, which is why we only react to cannabis, he claimed. One group of rats received CBD injections only, whereas another received injections of both CBD and tetrahydrocannabinol (THC), the hallucinogenic ingredient in marijuana and hashish. After testing the combined administration of THC and CBD in the rats, they discovered that CBD by alone supplied the essential therapeutic stimulus to hasten the healing of the femur. We discovered that CBD was adequate on its own to speed up fracture healing, according to Gabet.
We believe we should pursue this line of research in clinical trials to determine whether CBD is effective for enhancing human fracture healing because other studies have also demonstrated that it is a safe agent.
Given that osteoporosis is thought to be the cause of more than 8.9 million fractures worldwide each year, the possibility of utilizing CBD as a prophylactic approach is also highly intriguing.
At this time, there is no disputing the clinical promise of molecules related to cannabinoids, according to Gabet. “While there is still much to be done to produce effective medicines, it is evident that a therapeutic therapy objective may be separated from cannabis’ psychoactivity. The main component of our study, CBD, has no psychoactivity and is essentially anti-inflammatory.
Cannabis; Its Use In Osteoporosis
Cannabis for bone fractures and strengthing has currently, there is little study on CBD’s ability to treat osteoporosis. The endocannabinoid system of the body and CBD interact, which is the first thing to understand about studies in this field. This intricate cell-signaling system is involved in the control of several body processes, including memory, mood, and sleep.
Some 2012 studies contend that the control of bone mass involves the skeletal endocannabinoid system. Animal studies from 2020 Trusted Source have demonstrated that CBD may speed up bone mending by activating cannabinoid receptors.
A review by 2020Trusted Source discovered that CBD therapy enhanced bone repair, however, this study still has to be confirmed in clinical trials. It’s still crucial
to take any supplements or drugs that your doctor has given even while we wait for results from clinical trials. Do not rely solely on CBD to manage bone health issues. CBD mustn’t be thought of as a “cure-all” for any illness, including osteoporosis.
Smoking has detrimental effects on bone health and healing and is one of the most modifiable risk factors for osteoporosis and bone fractures. Smokers who undergo orthopedic surgery run the risk of problems such delayed bone as healing, infection, fractures, and nonunion of the bones.
Cannabis; Healing Agent
Although cannabis (marijuana and hashish) has not been linked to any skeletal effects, cannabinoid ligands modulate bone mass. Bone fractures are very common and result in prolonged agony and immobility. Here, we find that cannabidiol (CBD), the main non-psychoactive cannabis component, improves the biomechanical characteristics of healing rat mid-femoral fractures. CBD significantly raised the maximum load and work-to-failure, but not the stiffness, of the femurs of rats that had been given a combination of CBD and 9-tetrahydrocannabinol (THC) for eight weeks. THC, the psychoactive ingredient in cannabis, does not share this impact; nevertheless, after 6 weeks after fracture, THC amplifies the CBD-stimulated work-to-failure, and at 8 weeks, it attenuates the CBD effect. Data reveal the important mechanical role of collagen crosslinking enzymes and indicate how CBD improves fracture repair.
Cannabidiol; Impact On Bone Healing
Cannabis’ key element, cannabidiol (CBD), has recently become more well-known thanks to intensive marketing and advertising. Only extremely pure CBD has received approval from the Food and Drug Administration for the treatment of epilepsy. Many businesses, however, make unsubstantiated claims that CBD may treat a wide range of medical conditions, such as acne, anxiety, opiate addiction, pain, and menstruation issues. Many orthopedic patients may use cannabis medicines during the perioperative period given the rising popularity of marijuana use and CBD advertising. Cannabinoids are known to affect the body in a variety of ways, particularly in the musculoskeletal system. An increasing body of research is being done on the usage of cannabis, its biomechanical effects on the musculoskeletal system, and how they affect the results of orthopedic surgery. This review’s main goal is to objectively evaluate the most recent information on the effects of cannabinoids on the musculoskeletal system and how they are used to treat musculoskeletal illnesses.
By bolstering the “bridge” of cartilage that forms when a bone is healing, CBD improved bone repair. The collagen that makes up this bridge, known as the fracture callus, progressively mineralizes and hardens into new bone.
Δ9– Tetrahydrocannabiol; Impact On Bone Healing
-THC has a higher affinity for the CB1 receptor than the CB2 receptor, but it is a partial agonist of both. The neurological system’s CB1 receptors are activated by 9-THC, which has impacts on synaptic activity, motor function, pain perception, and hunger. The euphoric benefits of marijuana are caused by this neural system stimulation, which also frequently causes memory loss and an elevated risk of psychosis.
Even though it activates CB1 receptors, 9-THC may be harmful to bone repair. In addition to inhibiting osteogenesis, 9-THC also causes cell death in a variety of cell types, including neurons and mesenchymal stem cells, most likely through a mitochondrial mechanism that promotes apoptosis.
Scientific Evidence
Evidence of research demonstrating the effectiveness of medicinal marijuana in treating pain and several other ailments such as diabetes, Parkinson’s disease, cancer, and multiple sclerosis continues to rise.
Researchers from Tel Aviv University and the Hebrew University of Jerusalem recently reported their findings in the Journal of Bone and Mineral Research, showing that cannabidiol (CBD), one of marijuana’s non-psychoactive cannabinoids, significantly accelerated the recovery of lab rats with mid-femoral (thighbone) fractures.
The same researchers found that cannabinoid receptors in our bodies boosted bone development and prevented bone loss in the earlier study. This opens the door for cannabis medications to be used in the future to treat bone ailments like osteoporosis.
According to Gabet, “We discovered that CBD alone strengthens bones during healing by boosting the maturation of the collagenous matrix, which serves as the foundation for new mineralization of bone tissue. “The mended bone will be more difficult to shatter in the future after receiving CBD treatment.”
Mode Of Action
The two G protein-coupled CB1 and CB2 receptors are the primary endogenous cannabinoid receptors that are located throughout the body. The central and peripheral nerve systems contain CB1 receptors, which affect pain, mood, and appetite. Immune cells include CB2 receptors, which control cytokine production and inflammation. Both osteoblasts and osteoclasts express such receptors. Since CBD does not directly bind receptors like THC does but instead influences downstream signaling indirectly, the mechanism of action of CBD is not fully understood. The dopamine, serotonin, and opioid receptors are just a few of the non-cannabinoid receptors that CBD has been shown to bind with affinity to.
Dr. Abrams claims that while cannabis’ potential to lessen fracture-related pain is yet hypothetical, it may speed up bone repair. He points out that the Israeli study wasn’t conducted on humans, but rather on rats with broken thighbones. The effectiveness of the tested substance in treating human fractures is still unknown. Dr. Abrams claims that while cannabis’ potential to lessen fracture-related pain is yet hypothetical, it may speed up bone repair. He points out that the Israeli study wasn’t conducted on humans, but rather on rats with broken thighbones. The effectiveness of the tested substance in treating human fractures is still unknown. The main ingredients in cannabis, cannabinoids, have receptors expressed in bone cells. Additionally, there are many cannabinoid 1 (CB1) receptors in the brain. We feel the “high” associated with cannabis when these receptors bind with delta-9 tetrahydrocannabinol, or THC, the major psychoactive cannabinoid in the plant. According to Dr. Abrams, the reason why humans and all other animals, even sponges, have cannabinoid receptors that were designed to consume cannabis, but rather that we produce endogenous cannabinoids on our own (endocannabinoids). The modulation of pain is one of the most crucial physiologic processes in that these chemicals are involved. Cannabidiol is a different plant cannabinoid that has
attracted a lot of scientific interest (CBD). Despite not being psychotropic, CBD contains anti-inflammatory and pain-relieving properties.
Prevent Bone Fractures
Numerous treatments and lifestyle modifications can lower a person’s risk of bone fractures. Diet can influence a person’s risk of fractures. The body needs enough calcium to maintain strong bones. Calcium-rich foods include milk, cheese, yogurt, and dark-green leafy vegetables. Vitamin D is also necessary for the body to absorb calcium. Eggs, oily salmon, and sun exposure are all excellent sources of vitamin D.
Engaging in weight-bearing exercises can help improve muscle mass and bone density. Both of these can reduce the risk of bone fractures. In persons with osteoporosis, frequent activity and a healthy diet can lower their risk of fracture. Additionally, estrogen levels, which are important for bone health, significantly decrease the following menopause. This increases the risk of osteoporosis and fractures and makes calcium management more challenging. Therefore, during and after menopause, people should pay extra attention to the density and strength of their bones.
Conclusion Of Cannabis For Bone Fractures and Strengthing
Cannabis has almost 200 components. The two main components CBD and THC have their effect on the bone healing process. CBD helps in the process of healing in bones while THC causes cell death hindering the healing process. CBD helped rats with induced thigh bone fractures heal more quickly. In addition to seeming stiffer, the repaired bone in the CBD-treated rats likely had a stronger
structure. Animals receiving CBD appeared to have stronger fractures than those treated with THC alone, while a CBD and THC combination performed no better than CBD alone. The researchers concluded that CBD for fracture healing should be tested on humans. The experiments on cannabis usage were done on rats. Their benefits for bone fracture is theoretical. Further research will disclose their real impact.
Thank you for reading about Cannabis For Bone Fractures and Strengthing. We have many more articles that explain how cannabis can help with many illnesses written by medical doctors. Check those out in our blog section.
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